Oleanolic acid yog ib hom pentacyclic triterpenoids tau los ntawm kev sib cais thiab rho tawm los ntawm cov txiv hmab txiv ntoo ntawm tag nrho cov nroj tsuag ntawm Gentianaceae cog, genus ntawm genus Syringa japonica los yog Ligustrum lucidum. Cov kev tshawb fawb tshuaj niaj hnub no tau lees paub tias oleanolic acid tuaj yeem txo qhov nce siab ntawm cov ntshav alanine aminotransferase, txo lub siab cell degeneration thiab necrosis, daim siab cov ntaub so ntswg inflammatory thiab fibrosis txheej txheem, txhawb lub siab cell regeneration, accelerate kho daim siab necrotic ntaub so ntswg, inhibit qhov tsis- tshwj xeeb inflammatory teb, thiab muaj cov nyhuv ntawm kho cov protein metabolism tsis zoo. Kev soj ntsuam ultrastructural qhia tau hais tias oleanolic acid tuaj yeem tiv thaiv thiab ruaj khov ntawm lysosomal membrane thiab biofilm ntawm organelles, rov qab nws cov permeability thiab kev thauj mus los ua haujlwm, rov ua kom lub zog ntawm intracellular thiab extracellular ions thiab dej, thiab loosen lub cytoplasm thiab balloon zoo li hepatocytes rov qab los. ib txwm, lub peev xwm rov tsim dua tshiab yog txhim kho, thiab daim siab fibrosis yog tiv thaiv thiab inhibited. Cov kev sim hauv vitro tau pom tias oleanolic acid tuaj yeem cuam tshuam kev loj hlob ntawm leukemia hlwb los ntawm kev txo qis kev qhia ntawm vascular endothelial kev loj hlob. Nws yog qhov tsim nyog rau kev kho tus kab mob siab viral, thiab nws tuaj yeem txhim kho cov tsos mob, cov cim qhia thiab lub siab ua haujlwm, kho cov protein metabolism tsis zoo thiab muaj qee yam kev tiv thaiv qog.
Hais txog kev nyab xeeb, cov neeg mob me me tau hnov qhov ncauj qhuav, raws plab, thiab mob plab plab tom qab noj oleanolic acid, uas ploj mus tom qab kev kho mob. Mob thrombocytopenia me me tshwm sim hauv ib tus neeg mob, uas tuaj yeem rov zoo tom qab tso tseg cov tshuaj.
Matrine yog ib hom alkaloid rho tawm thiab cais los ntawm Sophora japonica, ib tsob nroj ntawm genus Sophora genus, feem ntau yog oxymatrine, thiab muaj me me ntawm oxymatrine. Matrine muaj cov nyhuv ntawm leukocytes nce, thiab tseem muaj cov nyhuv curative ntawm leukopenia; nws muaj kev tiv thaiv ntawm daim siab raug mob, serum alanine aminotransferase txo, daim siab necrosis thiab o raug txo, thiab daim siab kho cov ntaub so ntswg yog nce; nyob rau hauv vitro thiab hauv vivo thwmsim qhia tau hais tias, Nws muaj qee yam kev cuam tshuam ntawm inhibiting replication ntawm tus kab mob siab B; Nws tuaj yeem txo cov permeability ntawm capillaries, inhibit qhov kev loj hlob ntawm cov ntaub so ntswg granulation, tswj kev tso tawm ntawm histamine, leukotrienes thiab lwm yam kev sib kho los ntawm daim siab mast hlwb, thiab inhibit qhov tso tawm ntawm leukocytes los ntawm lipopolysaccharide-induced nas peritoneal macrophages. Cytokines xws li IL-1, interleukin-6, qog necrosis factor-, thiab lwm yam, muaj cov tshuaj uas tsis yog tshuaj steroidal xws li tshuaj tiv thaiv kab mob thiab tiv thaiv kev ua xua; tuaj yeem inhibit qhov kev loj hlob ntawm hepatic stellate hlwb thiab muaj kev tiv thaiv kab mob siab fibrosis; Immunomodulatory nyhuv, thiab tuaj yeem tiv thaiv lossis ncua qhov tshwm sim ntawm daim siab mob cancer. Nws yog qhov tsim nyog rau kev kho mob ntawm tus kab mob siab B, kab mob siab B fibrosis, leukopenia tshwm sim los ntawm qog xov tooj cua, tshuaj kho mob thiab leukopenia los ntawm lwm yam laj thawj. Adjuvant kev kho mob rau mob eczema thiab mob herpes zoster.
Hais txog kev nyab xeeb, cov tshuaj tiv thaiv tsis zoo ntawm matrine yog qhov nce ntxiv ntawm alanine aminotransferase, uas tuaj yeem txhim kho nrog kev siv tshuaj txuas ntxiv. Tej zaum yuav muaj xeev siab, ntuav, iab saj, raws plab, epigastric tsis xis nyob los yog mob, thiab lwm yam. Qee zaus, daim tawv nqaij ua pob khaus, mob hauv siab, thiab kub taub hau tuaj yeem tshwm sim, thiab cov tsos mob saum toj no feem ntau txo lawv tus kheej.
Silibinin yog cov tshuaj antioxidant, muab rho tawm los ntawm cov nroj tsuag hu ua mis thistle, uas tuaj yeem txhim kho daim siab cell daim nyias nyias, tiv thaiv cov enzyme system ntawm daim siab hlwb, tshem tawm cov reactive oxygen radicals nyob rau hauv daim siab hlwb, li no pab kom lub siab detoxification muaj peev xwm, txhim kho daim siab ua hauj lwm thiab txhawb lub siab cell regeneration. . Cov txiaj ntsig ntawm kev sim tshuaj thiab tshuaj toxicological qhia tias silibinin muaj ntau qib ntawm kev tiv thaiv thiab kho cov teebmeem ntawm ntau hom kev puas siab puas ntsws los ntawm daim siab mob, tshuaj tiv thaiv kab mob, sepsis, thiab lwm yam, thiab tuaj yeem tiv thaiv qhov nce ntawm aminotransferase rau qee yam. nyhuv. Cov txiaj ntsig kuaj pom tau hais tias silibinin tuaj yeem cuam tshuam lub siab cell proliferation thiab collagen synthesis, muaj qee yam kev tiv thaiv fibrotic, tuaj yeem tiv thaiv kev mob ntshav qab zib los ntawm kev txhim kho lipid peroxide tshem tawm, thiab tuaj yeem ua rau muaj kev nkag siab ntawm insulin hauv vivo. Nws yog qhov tsim nyog rau kev kho mob ntawm lub siab ua haujlwm tsis zoo hauv cov tshuaj lom thiab tiv thaiv lub siab puas tsuaj, mob siab thiab mob ntev, thiab haus dej cawv fatty siab. Thiab muaj qee yam antagonism ntawm daim siab fibrosis. Nws muaj qee yam kev tiv thaiv thiab kho cov teebmeem ntawm cov teeb meem ntshav qab zib thiab cov kab mob tiv thaiv insulin. Thaum siv los kho cov rog rog thiab daim siab cirrhosis, nws raug nquahu kom tsis txhob noj cov zaub mov muaj roj ntau dhau. Kev kho mob tuaj yeem siv los kho lub siab puas tsuaj los ntawm kev haus dej cawv ntev ntev thiab haus luam yeeb.
