Muaj peev xwm txuas lub neej ntawm Caenorhabditis elegans
Thaum nws los txog rau chlorogenic acid poob phaus, qee tus neeg yuav paub nws. Chlorogenic acid muaj ntau yam kev ua haujlwm lom, thiab kev tshawb fawb niaj hnub tshawb fawb txog nws cov dej num lom neeg tau nkag mus rau ntau qhov chaw xws li zaub mov, saib xyuas kev noj qab haus huv, tshuaj thiab tshuaj lom neeg niaj hnub.
Chlorogenic acid muaj nyob hauv ntau cov nroj tsuag, xws li tshuaj yej, kas fes, honeysuckle, thiab lwm yam. Nws yog ib qho ntawm cov tshuaj tua kab mob thiab tshuaj tua kab mob muaj txiaj ntsig zoo hauv ntau yam tshuaj ntsuab suav thiab cov khoom lag luam. Hauv kev tshawb fawb dhau los, cov kws tshawb fawb tau tshawb pom tias chlorogenic acid ntxiv muaj ntau yam cuam tshuam xws li tshuaj tua kab mob, tshuaj tua kab mob, txhim kho cov ntshav dawb, tiv thaiv daim siab thiab choleretic, tiv thaiv qog nqaij hlav, txo ntshav siab, txo cov ntshav lipid, tshem tawm cov dawb radicals, thiab txaus siab rau lub hauv paus paj hlwb. . Txawm li cas los xij, cov txiaj ntsig thiab cov txheej txheem ntawm chlorogenic acid ntawm kev laus tsis tau paub meej.
& quot; Tshuaj yej thiab kas fes yog cov dej haus niaj hnub siv tshaj plaws hauv ntiaj teb. Tib neeg tau ua kev tshawb fawb dav dav txog kev ua haujlwm ntawm lub cev ntawm ob yam tshuaj no. Peb tau tshawb fawb cov ntaub ntawv thiab pom tias feem ntau ntawm cov tshuaj yej thiab kas fes, chlorogenic acid hauv tshuaj yej, muaj cov tshuaj tiv thaiv kab mob, thiab Nws muaj kev tiv thaiv kev tiv thaiv kab mob ntsig txog kev laus. Yog li ntawd, peb xav tias cov tshuaj chlorogenic acid tuaj yeem tiv thaiv kev laus." Luo Huairong hais rau tus kws tshaj xov xwm los ntawm Tuam Tshoj Science Daily.
Luo Huairong' pab pawg tshawb fawb pib siv Caenorhabditis elegans ua qauv los tshawb fawb txog kev tiv thaiv kev laus ntawm chlorogenic acid thiab nws cov txheej txheem." Caenorhabditis elegans yog tus qauv kab mob rau kev tshawb fawb laus. Nws muaj lub neej luv luv ntawm tsuas yog 2 txog 3 lub lis piam. Nws muaj lub cev ua haujlwm tau meej thiab keeb kwm keeb kwm caj ces. Muaj ntau ntau yam kev hloov pauv caj ces uas tuaj yeem siv tau, thiab nws yog qhov yooj yim los ua kev txheeb xyuas lub cev teeb tsa kev tshuaj xyuas ntawm txhua qib tsiaj." Hais txog kev siv Caenorhabditis elegans ua tus qauv, Luo Huairong piav qhia.
Tom qab kev tshawb fawb ib txwm muaj, kev tshawb pom ntawm Luo Huairong' pab pawg tau lees paub thawj qhov kev xav tias chlorogenic acid hauv kas fes ntsuab tuaj yeem txuas lub neej ntawm hom tsiaj qus C. elegans los ntawm 20.1%.
kev twv ua ntej rau tib neeg
Yuav ua li cas chlorogenic acid ua tiav qhov kev tiv thaiv kev laus? Luo Huairong' pawg tshawb fawb pom tias chlorogenic acid tuaj yeem ua rau txoj hauv kev taw qhia cov tshuaj insulin, txo qib phosphorylation ntawm AKT, qhib kev qhia tawm cov lus hloov pauv DAF-16 thiab nws cov noob qis, thiab nce kev tiv thaiv ntawm nematodes rau ib puag ncig kev ntxhov siab sab nraud, yog li ua kom lub neej ntev ntawm nematodes.
DAF-16 noob yog tus tswj kav lub neej. Cov kev tshawb fawb yav dhau los ua los ntawm cov kws tshawb fawb ntawm kab mob cab tau pom tias DAF-16 noob muaj feem cuam tshuam nrog kev ua neej nyob ntev thiab tiv thaiv kab mob.
Raws li Luo Huairong, tib neeg kev laus yog tus cwj pwm los ntawm kev ua kom lub cev tsis muaj zog tas li, uas ua rau muaj kev ua haujlwm tsis zoo thiab ua rau muaj kev pheej hmoo tsawg, thiab thaum kawg ua rau tuag. Qhov kev puas tsuaj no yog tib neeg muaj kab mob loj, suav nrog cov teeb meem loj rau mob qog noj ntshav, ntshav qab zib, kab mob hauv lub plawv, thiab kab mob neurodegenerative.
& quot; Hauv xyoo tsis ntev los no, kev tshawb fawb txog kev laus tau ntsib qhov kev vam meej tsis tau pom dua, tshwj xeeb yog kev tshawb pom tias tus nqi ntawm kev laus tuaj yeem tswj tau, thiab kev tshuaj ntsuam caj ces thiab cov txheej txheem biochemical ntawm kev laus yog kev txuag hauv kev hloov pauv." Luo Huairong tau hais tias kev laus ntawm cov kab mob sib txawv muaj cov cim tshwm sim. Cov yam ntxwv ntawm kev sib deev, xws li kev tsis sib xws hauv genome, kev ploj ntawm telomere, kev hloov pauv hauv epigenetic, poob ntawm cov protein homeostasis, kev tswj hwm kev noj zaub mov tsis raug cai, mitochondrial tsis ua haujlwm, cellular senescence, qia cell depletion, kev hloov pauv hauv kev sib txuas lus, thiab lwm yam. txheeb xyuas kev sib raug zoo ntawm cov cim ntawm kev laus thiab lawv pab txhawb rau kev laus, thiab thaum kawg txhawm rau txheeb xyuas lub hom phiaj tshuaj txhawm rau txhim kho kev noj qab haus huv ntawm tib neeg lub cev thaum txheej txheem kev laus nrog qhov tshwm sim tsawg.
Yog li ntawd, pab pawg tshawb fawb Luo Huairong tau cog lus tias yuav siv tus qauv tsiaj C. elegans los kawm cov txheej txheem ntawm kev laus, thiab siv cov cell thiab nematode qauv los tsim tshuaj tiv thaiv kev laus. Kev tshawb fawb txog kev tiv thaiv kev laus thiab cov txheej txheem ntawm chlorogenic acid yog ib qho ntawm lawv. Tam sim no, Luo Huairong' pab pawg tau ua tiav kev tshuaj xyuas ib pawg ntawm cov tshuaj sib xyaw nrog kev tiv thaiv kev laus, thiab tab tom kawm nws cov txheej txheem ntawm kev nqis tes ua.
Chlorogenic acid tuaj yeem ua lub neej ntev ntawm Caenorhabditis elegans. Qhov no puas txhais tau tias nws tseem yuav muaj txiaj ntsig zoo rau tib neeg kev tiv thaiv kev laus? Hauv qhov no, Luo Huairong piav qhia tias vim tias cov txheej txheem ntawm kev laus yog tam sim no tau txiav txim siab ntau, uas yog, kev tswj hwm cov hnub nyoog qhia ntawm cov tsiaj sib txawv xws li cov poov xab, nematodes, yoov txiv hmab txiv ntoo, nas, thiab cov tsiaj txhu yog qhov zoo ib yam. Yog li ntawd, kev tshawb fawb pom ntawm nematodes muaj qhov ua tau zoo yav tom ntej ntawm tib neeg." Tau kawg, qhov tshwm sim tiag tiag tsuas yog tuaj yeem lees paub los ntawm kev kuaj mob hnyav."
