Siv A transgenic nematode strain CL2006 ua tus qauv, cov kws tshawb fawb hauv Chang Chen pab pawg tau ntxiv LBE rau cov zaub mov nematode E. coli OP50 ntawm ib qho concentration thaum lub sij hawm larval L4 los tshawb xyuas cov kev ua haujlwm thiab molecular mechanisms ntawm LBE hauv tshuaj lom A ntau lawm thiab tshem tawm. . LBE tau pom tias txo qis kev sib sau ua ke ntawm A thiab yog li txo cov leeg tuag tes tuag taw phenotype ntawm CL2006 nematodes. Ntawm qhov tod tes, LBE muaj zog antioxidant kev ua haujlwm thiab tuaj yeem cuam tshuam kev tsim khoom thiab sib sau ua ke ntawm A los ntawm kev ua kom SKN -1 txoj hauv kev los tiv thaiv kev tsim tawm ntau tshaj ROS (Reactive oxygen hom). Ntawm qhov tod tes, LBE tuaj yeem qhib lub mitochondrial unfolded protein teb (mtUPR) hauv CL2006 nematodes. Kev cuam tshuam nrog kev qhia ntawm cov noob tseem ceeb mtUPR thim rov qab LBE-mediated txo qis hauv qib A thiab txhim kho cov leeg nematode leeg tuag tes tuag taw phenotype. Txawm li cas los xij, cuam tshuam nrog kev qhia ntawm cov noob tseem ceeb hauv lwm txoj hauv kev cuam tshuam nrog cov protein degradation, xws li proteasome system, autophagic pathway thiab endoplasmic reticulum unfolded protein teb (ERUPR), tsis inhibit LBE-vim txo qis hauv qib A. Ntxiv mus, cuam tshuam nrog kev qhia ntawm G protein-coupled receptor gene FSHR{10}} inhibited qhov ua kom mtUPR los ntawm LBE. Yog li, LBE inhibits A aggregation thiab tswj cov protein homeostasis los ntawm FSHR{11}}kev ua kom sib haum xeeb ntawm mtUPR, yog li tiv thaiv kev puas tsuaj mitochondrial ntxiv.
Txoj kev tshawb no qhia txog thawj zaug uas LBE ua rau muaj kev tiv thaiv ntawm AD qauv nematodes los ntawm kev ua kom lub mitochondrial UPR, muab ib lub tswv yim tshiab los qhia txog qhov tseem ceeb ntawm LBP hauv kev tiv thaiv thiab kho AD. Tsis zoo li cov kev tshawb fawb yav dhau los ntawm UPR hauv AD uas feem ntau tau tsom mus rau endoplasmic reticulum UPR, txoj kev tshawb no muab pov thawj tshiab rau lub luag haujlwm cytoprotective ntawm mitochondrial UPR hauv chav kawm AD. Tsis tas li ntawd, ntau yam kab mob neurodegenerative sib txawv tuaj yeem sib koom ua ke thiab cov txheej txheem pathological - protein misfolding thiab aggregation. Yog li, txoj kev tshawb no tseem muab cov ntaub ntawv tshiab rau kev tiv thaiv thiab kho cov kab mob neurodegenerative los ntawm kev txhim kho cov mitochondrial UPR.
