Cov kab mob uas tsis yog-alcoholic fatty siab (NAFLD) yog kab mob siab tshaj plaws, thiab tseem tsis muaj cov tshuaj kho mob zoo. Ntau cov kev tshawb fawb tau pom tias cov kab mob hauv plab hnyuv yog ib qho tseem ceeb hauv kev tsim cov kab mob rog rog-based metabolic. Yog li ntawd, lub hom phiaj ntawm txoj hnyuv plab yog suav tias yog ib qho tseem ceeb tshiab lub tswv yim rau kev tiv thaiv thiab kho cov kab mob metabolic. Polysaccharides yog ib chav kawm ntawm natural macromolecular compounds dav dav hauv cov tshuaj suav tshuaj. Ntau cov kev tshawb fawb tau pom tias cov nroj tsuag polysaccharides muaj qhov cuam tshuam meej rau kev tswj hwm ntawm lub cev metabolism, tab sis qhov tseeb mechanism tsis meej kiag li.
Pab neeg ntawm Prof. Houkai Li tau lees paub hauv txoj kev tshawb fawb dhau los hais tias qhov tseem ceeb ntawm Qi txhawb nqa cov tshuaj suav tshuaj Astragalus, astragalus polysaccharide, muaj cov txiaj ntsig ntawm kev txhim kho kev rog rog thiab NAFLD, thiab los ntawm kev sib xyaw ua ke nrog kev tshuaj ntsuam xyuas metabolomic uas tsis yog tsom rau, nws tau pom tias Astragalus polysaccharide muaj kev cuam tshuam rau txoj hnyuv. Kev tswj hwm cov txiaj ntsig ntawm microbiota thiab microbiota metabolites tau npaj "tshuaj-kab mob microbiota-microbiota metabolite-host metabolism" kev sib raug zoo axis hypothesis tias astragalus polysaccharides txhim kho NAFLD tsim. Raws li qhov kev xav ntawm kev tshawb fawb no, pab pawg tshawb fawb tau tshawb xyuas cov kab mob hauv plab tshwj xeeb thiab cov metabolites cuam tshuam los ntawm astragalus polysaccharides los ntawm ntau lub tswv yim ua ke. Cov kab mob plab, Desulfovibrio vulgaris. Kev tshawb fawb ntxiv tau lees paub tias cov kab mob tsis yog tsuas yog H2S-ua cov kab mob, tab sis kuj muaj peev xwm tsim cov acetic acid nrog kev ua haujlwm siab. Exogenous supplementation ntawm cov kab mob no tuaj yeem txhim kho daim siab steatosis, insulin rhiab heev thiab qhov hnyav nce hauv cov nas uas muaj rog ntau. Lub siab RNA seq tsom xam thiab kev tshawb fawb molecular biology tau lees paub tias kev txhim kho ntawm NAFLD muaj feem cuam tshuam nrog kev cuam tshuam ntawm daim siab FASN thiab CD36 protein qhia. Txoj kev tshawb no muab cov ntaub ntawv pov thawj tshiab los piav qhia txog cov txheej txheem ntawm astragalus polysaccharides hauv kev txhim kho NAFLD, thiab tseem muab cov ntaub ntawv siv rau kev tshawb nrhiav cov txheej txheem ntawm cov nroj tsuag polysaccharides tswj cov hnyuv thiab txhim kho cov metabolism hauv lub cev los ntawm kev siv tshuab ntau yam omics.
